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KMID : 1098420040120060463
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Korean Journal of Medicinal Crop Science
2004 Volume.12 No. 6 p.463 ~ p.472
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Chemical Composition and Biological Activities of Elsholtzia ciliata (Thunb.) Hylander
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Jeong Jae-Hoon
Lim Heung-Bin
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Abstract
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This study was carried out to investigate the chemical composition of essential oils, absolutes and oleoresins isolated from Elsholtzia ciliata and the biological activities of them. Yields of essential oils, absolutes and oleoresins were 0.34%, 11.33% and 15.24%, respectively. The major component was naginate ketone in essential oils, methyl linolenate in absolutes and 9,12,15-octadecatrienoic acid in oleoresins. Eseential oils and oleoresins showed the inhibitory activities in enzyme-dependent, enzyme-independent and autooxidatve lipid peroxidation systems. EC_{50} values in neutral red uptake assays 24 h of exposure times were 23.3;{mu}g/m{ell}, 341.0;{mu}g/m{ell} and 17.2;{mu}g/m{ell} in essential oils, absolutes and oleoresins, respectively, and essential oils and oleoresins showed the cytotoxic effect at the only high dose. Absolutes and oleoresins did not show antibiotic and mutagenic activities. On the contrary, essential oils with over 500;{mu}g/plate showed antibiotic and mutagenic activities in Ames test. Essential oils and oleoresins have a prolongating effect the ciliostasis of rat trachea.
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KEYWORD
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Elsholtzia ciliata, volatile flavor components, lipid peroxidation, NRU assay, Ames test, ciliostasis
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